Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis
Identifieur interne : 001A50 ( Main/Exploration ); précédent : 001A49; suivant : 001A51Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis
Auteurs : K. A. Elisa Kallio [Finlande] ; Marja Marchesani [Finlande] ; Efthymia Vlachopoulou [Finlande] ; P Ivi M Ntyl [Finlande] ; Susanna Paju [Finlande] ; K Re Buhlin [Finlande, Suède] ; Anna L. Suominen [Finlande] ; Johanna Contreras [Chili] ; Matti Knuuttila [Finlande] ; Marcela Hernandez [Chili] ; Sisko Huumonen [Finlande] ; Markku S. Nieminen [Finlande] ; Markus Perola [Finlande] ; Juha Sinisalo [Finlande] ; Marja-Liisa Lokki [Finlande] ; Pirkko J. Pussinen [Finlande]Source :
- Infection and Immunity [ 0019-9567 ] ; 2014.
Abstract
Periodontitis is a chronic inflammatory disease with a multifactorial etiology. We investigated whether human major histocompatibility complex (MHC) polymorphisms (6p21.3) are associated with periodontal parameters. Parogene 1 population samples (
Url:
DOI: 10.1128/IAI.01681-13
PubMed: 24566624
PubMed Central: 3993418
Affiliations:
- Chili, Finlande, Suède
- Finlande occidentale, Uusimaa
- Helsinki, Turku
- Université d'Helsinki, Université de Turku
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002329
- to stream Pmc, to step Curation: 002329
- to stream Pmc, to step Checkpoint: 001454
- to stream Ncbi, to step Merge: 004E69
- to stream Ncbi, to step Curation: 004E69
- to stream Ncbi, to step Checkpoint: 004E69
- to stream Main, to step Merge: 001A57
- to stream Main, to step Curation: 001A50
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic Variation on the <italic>BAT1-NFKBIL1-LTA</italic> Region of Major Histocompatibility Complex Class III Associates with Periodontitis</title><author><name sortKey="Kallio, K A Elisa" sort="Kallio, K A Elisa" uniqKey="Kallio K" first="K. A. Elisa" last="Kallio">K. A. Elisa Kallio</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Marchesani, Marja" sort="Marchesani, Marja" uniqKey="Marchesani M" first="Marja" last="Marchesani">Marja Marchesani</name><affiliation wicri:level="4"><nlm:aff id="aff2">Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Vlachopoulou, Efthymia" sort="Vlachopoulou, Efthymia" uniqKey="Vlachopoulou E" first="Efthymia" last="Vlachopoulou">Efthymia Vlachopoulou</name><affiliation wicri:level="4"><nlm:aff id="aff2">Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="M Ntyl, P Ivi" sort="M Ntyl, P Ivi" uniqKey="M Ntyl P" first="P Ivi" last="M Ntyl">P Ivi M Ntyl</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Paju, Susanna" sort="Paju, Susanna" uniqKey="Paju S" first="Susanna" last="Paju">Susanna Paju</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Buhlin, K Re" sort="Buhlin, K Re" uniqKey="Buhlin K" first="K Re" last="Buhlin">K Re Buhlin</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Periodontology, Institute of Odontology, Karolinska Institutet, Huddinge, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Periodontology, Institute of Odontology, Karolinska Institutet, Huddinge</wicri:regionArea><wicri:noRegion>Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Suominen, Anna L" sort="Suominen, Anna L" uniqKey="Suominen A" first="Anna L." last="Suominen">Anna L. Suominen</name><affiliation wicri:level="1"><nlm:aff id="aff4">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Institute of Dentistry, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff6">Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation></author><author><name sortKey="Contreras, Johanna" sort="Contreras, Johanna" uniqKey="Contreras J" first="Johanna" last="Contreras">Johanna Contreras</name><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Knuuttila, Matti" sort="Knuuttila, Matti" uniqKey="Knuuttila M" first="Matti" last="Knuuttila">Matti Knuuttila</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Periodontology and Geriatric Dentistry, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Periodontology and Geriatric Dentistry, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez, Marcela" sort="Hernandez, Marcela" uniqKey="Hernandez M" first="Marcela" last="Hernandez">Marcela Hernandez</name><affiliation wicri:level="1"><nlm:aff id="aff9">Laboratory of Periodontal Biology, Faculty of Dentistry, University of Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Laboratory of Periodontal Biology, Faculty of Dentistry, University of Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Huumonen, Sisko" sort="Huumonen, Sisko" uniqKey="Huumonen S" first="Sisko" last="Huumonen">Sisko Huumonen</name><affiliation wicri:level="4"><nlm:aff id="aff10">Institute of Dentistry, University of Turku, Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><affiliation wicri:level="1"><nlm:aff id="aff11">HUCH Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>HUCH Heart and Lung Center, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation wicri:level="1"><nlm:aff id="aff4">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation wicri:level="1"><nlm:aff id="aff11">HUCH Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>HUCH Heart and Lung Center, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><affiliation wicri:level="4"><nlm:aff id="aff2">Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J." last="Pussinen">Pirkko J. Pussinen</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24566624</idno><idno type="pmc">3993418</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993418</idno><idno type="RBID">PMC:3993418</idno><idno type="doi">10.1128/IAI.01681-13</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002329</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002329</idno><idno type="wicri:Area/Pmc/Curation">002329</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002329</idno><idno type="wicri:Area/Pmc/Checkpoint">001454</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001454</idno><idno type="wicri:Area/Ncbi/Merge">004E69</idno><idno type="wicri:Area/Ncbi/Curation">004E69</idno><idno type="wicri:Area/Ncbi/Checkpoint">004E69</idno><idno type="wicri:doubleKey">0019-9567:2014:Kallio K:genetic:variation:on</idno><idno type="wicri:Area/Main/Merge">001A57</idno><idno type="wicri:Area/Main/Curation">001A50</idno><idno type="wicri:Area/Main/Exploration">001A50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic Variation on the <italic>BAT1-NFKBIL1-LTA</italic> Region of Major Histocompatibility Complex Class III Associates with Periodontitis</title><author><name sortKey="Kallio, K A Elisa" sort="Kallio, K A Elisa" uniqKey="Kallio K" first="K. A. Elisa" last="Kallio">K. A. Elisa Kallio</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Marchesani, Marja" sort="Marchesani, Marja" uniqKey="Marchesani M" first="Marja" last="Marchesani">Marja Marchesani</name><affiliation wicri:level="4"><nlm:aff id="aff2">Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Vlachopoulou, Efthymia" sort="Vlachopoulou, Efthymia" uniqKey="Vlachopoulou E" first="Efthymia" last="Vlachopoulou">Efthymia Vlachopoulou</name><affiliation wicri:level="4"><nlm:aff id="aff2">Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="M Ntyl, P Ivi" sort="M Ntyl, P Ivi" uniqKey="M Ntyl P" first="P Ivi" last="M Ntyl">P Ivi M Ntyl</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Paju, Susanna" sort="Paju, Susanna" uniqKey="Paju S" first="Susanna" last="Paju">Susanna Paju</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Buhlin, K Re" sort="Buhlin, K Re" uniqKey="Buhlin K" first="K Re" last="Buhlin">K Re Buhlin</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Periodontology, Institute of Odontology, Karolinska Institutet, Huddinge, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Periodontology, Institute of Odontology, Karolinska Institutet, Huddinge</wicri:regionArea><wicri:noRegion>Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Suominen, Anna L" sort="Suominen, Anna L" uniqKey="Suominen A" first="Anna L." last="Suominen">Anna L. Suominen</name><affiliation wicri:level="1"><nlm:aff id="aff4">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Institute of Dentistry, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation><nlm:aff id="aff6">Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio Finland</nlm:aff><wicri:noCountry code="subfield">Kuopio Finland</wicri:noCountry></affiliation></author><author><name sortKey="Contreras, Johanna" sort="Contreras, Johanna" uniqKey="Contreras J" first="Johanna" last="Contreras">Johanna Contreras</name><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Department of Conservative Dentistry, Faculty of Dentistry, University of Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Knuuttila, Matti" sort="Knuuttila, Matti" uniqKey="Knuuttila M" first="Matti" last="Knuuttila">Matti Knuuttila</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Periodontology and Geriatric Dentistry, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Periodontology and Geriatric Dentistry, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez, Marcela" sort="Hernandez, Marcela" uniqKey="Hernandez M" first="Marcela" last="Hernandez">Marcela Hernandez</name><affiliation wicri:level="1"><nlm:aff id="aff9">Laboratory of Periodontal Biology, Faculty of Dentistry, University of Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Laboratory of Periodontal Biology, Faculty of Dentistry, University of Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Huumonen, Sisko" sort="Huumonen, Sisko" uniqKey="Huumonen S" first="Sisko" last="Huumonen">Sisko Huumonen</name><affiliation wicri:level="4"><nlm:aff id="aff10">Institute of Dentistry, University of Turku, Turku, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><affiliation wicri:level="1"><nlm:aff id="aff11">HUCH Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>HUCH Heart and Lung Center, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><affiliation wicri:level="1"><nlm:aff id="aff4">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation wicri:level="1"><nlm:aff id="aff11">HUCH Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>HUCH Heart and Lung Center, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><affiliation wicri:level="4"><nlm:aff id="aff2">Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J." last="Pussinen">Pirkko J. Pussinen</name><affiliation wicri:level="4"><nlm:aff id="aff1">Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Periodontitis is a chronic inflammatory disease with a multifactorial etiology. We investigated whether human major histocompatibility complex (MHC) polymorphisms (6p21.3) are associated with periodontal parameters. Parogene 1 population samples (<italic>n</italic> = 169) were analyzed with 13,245 single nucleotide polymorphisms (SNPs) of the MHC region. Eighteen selected SNPs (<italic>P</italic> ≤ 0.001) were replicated in Parogene 2 population samples (<italic>n</italic> = 339) and the Health 2000 Survey (<italic>n</italic> = 1,420). All subjects had a detailed clinical and radiographic oral health examination. Serum lymphotoxin-α (LTA) concentrations were measured in the Parogene populations, and the protein was detected in inflamed periodontal tissue. In the Parogene 1 population, 10 SNPs were associated with periodontal parameters. The strongest associations emerged from the parameters bleeding on probing (BOP) and a probing pocket depth (PPD) of ≥6 mm with the genes <italic>BAT1</italic>, <italic>NFKBIL1</italic>, and <italic>LTA</italic>. Six SNPs, rs11796, rs3130059, rs2239527, rs2071591, rs909253, and rs1041981 (<italic>r</italic><sup>2</sup>, ≥0.92), constituted a risk haplotype. In the Parogene 1 population, the haplotype had the strongest association with the parameter BOP, a PPD of ≥6 mm, and severe periodontitis with odds ratios (95% confidence intervals) of 2.63 (2.21 to 3.20), 2.90 (2.37 to 3.52), and 3.10 (1.63 to 5.98), respectively. These results were replicated in the other two populations. High serum LTA concentrations in the Parogene population were associated with the periodontitis risk alleles of the <italic>LTA</italic> SNPs (rs909253 and rs1041981) of the haplotype. In addition, the protein was expressed in inflamed gingival connective tissue. We identified a novel <italic>BAT1-NFKBIL1-LTA</italic> haplotype as a significant contributor to the risk of periodontitis. The genetic polymorphisms in the MHC class III region may be functionally important in periodontitis susceptibility.</p></div></front></TEI><affiliations><list><country><li>Chili</li><li>Finlande</li><li>Suède</li></country><region><li>Finlande occidentale</li><li>Uusimaa</li></region><settlement><li>Helsinki</li><li>Turku</li></settlement><orgName><li>Université d'Helsinki</li><li>Université de Turku</li></orgName></list><tree><country name="Finlande"><region name="Uusimaa"><name sortKey="Kallio, K A Elisa" sort="Kallio, K A Elisa" uniqKey="Kallio K" first="K. A. Elisa" last="Kallio">K. A. Elisa Kallio</name></region><name sortKey="Buhlin, K Re" sort="Buhlin, K Re" uniqKey="Buhlin K" first="K Re" last="Buhlin">K Re Buhlin</name><name sortKey="Huumonen, Sisko" sort="Huumonen, Sisko" uniqKey="Huumonen S" first="Sisko" last="Huumonen">Sisko Huumonen</name><name sortKey="Knuuttila, Matti" sort="Knuuttila, Matti" uniqKey="Knuuttila M" first="Matti" last="Knuuttila">Matti Knuuttila</name><name sortKey="Lokki, Marja Liisa" sort="Lokki, Marja Liisa" uniqKey="Lokki M" first="Marja-Liisa" last="Lokki">Marja-Liisa Lokki</name><name sortKey="M Ntyl, P Ivi" sort="M Ntyl, P Ivi" uniqKey="M Ntyl P" first="P Ivi" last="M Ntyl">P Ivi M Ntyl</name><name sortKey="Marchesani, Marja" sort="Marchesani, Marja" uniqKey="Marchesani M" first="Marja" last="Marchesani">Marja Marchesani</name><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><name sortKey="Paju, Susanna" sort="Paju, Susanna" uniqKey="Paju S" first="Susanna" last="Paju">Susanna Paju</name><name sortKey="Perola, Markus" sort="Perola, Markus" uniqKey="Perola M" first="Markus" last="Perola">Markus Perola</name><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J." last="Pussinen">Pirkko J. Pussinen</name><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><name sortKey="Suominen, Anna L" sort="Suominen, Anna L" uniqKey="Suominen A" first="Anna L." last="Suominen">Anna L. Suominen</name><name sortKey="Suominen, Anna L" sort="Suominen, Anna L" uniqKey="Suominen A" first="Anna L." last="Suominen">Anna L. Suominen</name><name sortKey="Vlachopoulou, Efthymia" sort="Vlachopoulou, Efthymia" uniqKey="Vlachopoulou E" first="Efthymia" last="Vlachopoulou">Efthymia Vlachopoulou</name></country><country name="Suède"><noRegion><name sortKey="Buhlin, K Re" sort="Buhlin, K Re" uniqKey="Buhlin K" first="K Re" last="Buhlin">K Re Buhlin</name></noRegion></country><country name="Chili"><noRegion><name sortKey="Contreras, Johanna" sort="Contreras, Johanna" uniqKey="Contreras J" first="Johanna" last="Contreras">Johanna Contreras</name></noRegion><name sortKey="Hernandez, Marcela" sort="Hernandez, Marcela" uniqKey="Hernandez M" first="Marcela" last="Hernandez">Marcela Hernandez</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A50 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A50 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3993418
|texte= Genetic Variation on the BAT1-NFKBIL1-LTA Region of Major Histocompatibility Complex Class III Associates with Periodontitis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24566624" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |